Brain Library The MBL consists of high-resolution images and databases of brains from many genetically characterized strains of mice.
"There are numerous uses of the MBL, but our own mission is to systematically map and characterize genes that modulate architecture of the mammalian CNS (for a complete description of our projects refer to our P20 Human Brain Project award: Informatics Center for Mouse Neurogenetics)." Search the library.
The iScope internet microscope to provide online realtime access to the slides which form the Mouse Brain
Library. Secure user authentication and scheduling ensures reliable, responsive
access to the system.
Mouse Phenome Databases & Mouse Colony Programs Browse or search the Mouse Brain Library (MBL).
The library contains high resolutions images (3060 x 2036 pixels, 25 µm per pixel)
of individual slides, usually two per case. We are in the process of acquiring
images for more than 1500 cases, usually 8 cases per strain cut in either the horizontal
or coronal planes. All sections are currently 30 µm-thick sections stained with cresyl violet
(an analine dye that preferentially stains RNA and DNA). Over 800 cases are now available.
This manual explains the process of embedding brain tissue in 12% celloidin, cutting the tissue with a microtome, staining and coverslipping the brain sections, the images of which are then posted on the internet for research purposes.
As of Gumbo v2.7 and Aria3D v1.5, these two components
of the iScope Client now feature more integration - specifically
the ability to launch Aria3D from within Gumbo. Click
here to download software,
and learn more.